|Topic:||Glyceraldehyde-3-Phosphate Dehydrogenase .|
|Details:||The second phase of glucose catabolism features the energy-yielding glycolytic reactions that produce ATP and NADH. In the first of these reactions, glyceraldehyde-3-P dehydrogenase (GAPDH, also abbreviated GAPD) catalyzes the NAD+-dependent oxidation of G3P to 1,3-bisphosphoglycerate (1,3BPG) with the simultaneous reduction of NAD+ to NADH. The GAPDH reaction is reversible, and the same enzyme catalyzes the reverse reaction during gluconeogenesis. Functional GAPDH enzyme exists as a homotetrameric complex. The GAPDH gene is located on chromosome 12p13.31 and is composed of 10 exons that generate five alternatively spliced mRNAs that encode three distinct protein isoforms identified as isoforms 1, 2, and 4.|
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