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    Peptide Synthesizer

    The two most common designs differ in their mode of liquid handling: the first relies on valves and valve blocks for distribution of reagents, while the second uses a robotic platform. They also differ in their mode of mixing the reactants in the reaction vessel, where the former can utilize sparging, 180┬░ rotational shaking, or vortexing, while the latter typically uses vortexing. Valve-based instruments are often single channel (one peptide at a time), but can also be expanded to allow parallel synthesis of up to 12 and even 24 peptides, however, at the price of added complexity. Valve systems often use inert gas for their operation. The X-Y robotic platforms are ideal for parallel synthesis of large numbers of peptides up to 192 and even peptide libraries. However, although less common, the robotic platform is also very suitable for single-channel operation and can also be used for operations under inert gas. Some single-channeled synthesizers are available with UV feedback monitoring of the Fmoc removal which can be useful for some applications. Importantly, single-channel synthesizers can be equipped with fast and precise microwave heating to accelerate the synthesis and to overcome synthetic difficulties. A whole range of synthesizers with different designs are commercially available. The choice of peptide synthesizer will depend on intended application, for example on the type of chemistry, scale, and the number of peptides that are required and so on.

    Company Name Description
    Biotage - Peptide Synthesis Instruments www.biotage.com

    Microwave and Room Temperature Peptide Synthesizers

    Biotage is the only manufacturer of room-temperature peptide synthesizers and microwave peptide synthesizers in both entry level and high throughput configurations. We offer a range of manual, semi-automated and fully automated systems for peptide synthesis depending on your needs. Whether you require a system that makes a single peptide or multiple peptides in parallel, we have an instrument to suit your requirements.
    CSBio - Automated Peptide Synthesizers www.csbio.com

    CSBio has been a leader in automated peptide synthesis since 1993. The company offers a versatile range of peptide synthesizers for research, process development, and large scale manufacturing. Our synthesizers have a wide range of reactor sizes from 10 mL to 1000 L and can be found in hundreds of peptide production laboratories across the globe.

    CSBio synthesizers can utilize both t-Boc and Fmoc chemistries which can be activated via HBTU/DIEA or HOBt/DIC or any other chemistry. They also have chemically inert, self-contained polypropylene cabinets.
    Microwave Peptide Synthesis - CEM Corporation www.cem.com
    AAPPTec www.aapptec.com

    APPTec manufactures automated peptide synthesizers for every production scale from research (a few milligrams) to pilot-plant and production (multi-kilograms). Our peptide instruments include the Endeavor 90, a benchtop automated peptide synthesizer with a long history of reliable service, the Apex 396, the leading peptide library synthesizer in the market, and the Titan 357, the first split-combine combinatorial peptide synthesizer. Our latest instruments include the Focus XC line of fully automated peptide synthesizers and the Apex 396HT for high throughput synthesis of peptide libraries in convenient 96 well titer plates.
    LabX www.labx.com

    The Liberty Blue system from CEM Corporation has been designed for maximized speed and efficiency. With 4 minute cycle times and a 90% solvent reduction, no other peptide synthesizer on the market can even come close to the performance of the Liberty Blue.
    Gyros Protein Technologies www.gyrosproteintechnologies.com

    Protein Technologies peptide synthesizers are designed to cover synthesis scales from 0.001 to 200 mmol. We offer a range of peptide synthesizers to meet your needs. Whether your chemistry is combinatorial, small organic molecules, peptide (Fmoc or t-Boc), peptoid or DNA, Protein Technologies has a peptide synthesizer for you. Researchers can get the flexible peptide synthesis capabilities they need for less by taking advantage of our Special Programs for Academia.
    Intavis intavis.com

    The MultiPep RSi, MultiPep CF, and ResPep SL are fully automated tabletop peptide synthesizers. Exchangeable modules cover synthesis scales for screenings with hundreds of peptides in parallel, the affordable production of specialty peptides in mini-columns or plates to the large scale synthesis of 100 mg peptide or more in column modules with agitation and heating options.
    Activotec: www.activotec.com

    The Activo-P11 Peptide Synthesizer is an easy to use and affordable instrument for synthesis of very high quality peptides. The Activo-P11 is the only synthesizer available with both automated reactor heating and UV monitoring. These valuable synthesis tools allow chemists to synthesize longer and more difficult peptides and to gain more synthesis information about those peptides. For example the antimicrobial peptide Gomesin has been successfully synthesized using conventional heating
    MultiSynTech: Automated Microwave and Parallel Peptide Synthesizer www.multisyntech.com

    Biotage® Syro Wa is the only programmable peptide synthesizer that is capable of both conventional room temperature parallel peptide synthesis and microwave assisted peptide synthesis. The system is fully automated and computer controlled utilizing a pipetting robot with a single arm.


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