|Topic:||Synthesis of the catecholamines from tyrosine. .|
|Details:||Tyrosine is converted to each of the three catecholamines through a series of four reactions. The tissue from which the neurotransmitter/hormone is derived expresses a specific set, or all, of these enzymes such that only dopamine (substantia nigra) is the result, or only norepinephrine (locus coeruleus), or both norepinephrine and epinephrine (adrenal medulla). DOPA decarboxylase (also known as aromatic L-amino acid decarboxylase) is encoded by the DDC gene. Dopamine β-hydroxylase is a critical vitamin C (ascorbate) and copper (Cu2+)-dependent enzyme. QDPR is quinoid dihydropteridine reductase which is more commonly just called dihydropteridine reductase. BH4 and 4α-BH2 are tetrahydrobiopterin and 4α-dihydrobiopterin, respectively.|
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