|Topic:||Synthesis of creatine and creatine phosphate .|
|Details:||The synthesis of creatine begins from arginine and glycine via the renal enzyme glycine amidinotransferase (GATM). The product, guanidinoacetate, is transported to the liver where it is methylated via the action of guanidinoacetate N-methyltransferase (GAMT) forming creatine. The methyl group is donated from S-adenosylmethionine (SAM). Creatine is released to the blood and picked up by the brain and skeletal muscle cells via the action of the SLC6A8 transporter. Creatine kinase (creatine phosphokinase) transfers a phosphate from ATP generating the high-energy intermediate, creatine phosphate.|
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