|Topic:||Principal pathway of polyamine synthesis in humans .|
|Details:||The key features of the pathway are that it involves putrescine, an ornithine catabolite, and S-adenosylmethionine (SAM; AdoMet) as a donor of two propylamine residues. The first propylamine conjugation yields spermidine and addition of another to spermidine yields spermine. The form of SAM utilized in the polyamine biosynthesis pathway is decarboxylated SAM (abbreviated dcSAM or dcAdoMet).|
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