|Topic:||Glucose Oxidation .|
|Details:||Aerobic glycolysis of glucose to pyruvate, requires two equivalents of ATP to activate the process, with the subsequent production of four equivalents of ATP and two equivalents of NADH. Thus, conversion of one mole of glucose to two moles of pyruvate is accompanied by the net production of two moles each of ATP and NADH.
Pathway of glycolysis from glucose to pyruvate: A larger vertical Figure is included in the Individual Reactions of Glycolysis section below. In this larger image one can mouse over structure names to see the chemical structures of the intermediates. The enzyme abbreviations are also identified in the Figure below.
The NADH generated during glycolysis is used to fuel mitochondrial ATP synthesis via oxidative phosphorylation, producing either two or three equivalents (approximately) of ATP depending upon whether the glycerol phosphate shuttle or the malate-aspartate shuttle is used to transport the electrons from cytoplasmic NADH into the mitochondria.
The net yield from the oxidation of one mole of glucose to two moles of pyruvate is, therefore, either 6 or 8 moles of ATP. Complete oxidation of the two moles of pyruvate, through the TCA cycle, yields an additional 30 moles of ATP; the total yield, therefore being either 36 or 38 moles of ATP from the complete oxidation of one mole of glucose to CO2 and H2O.
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