|Topic:||Glucose-6-phosphate isomerase .|
|Details:|| The second reaction of glycolysis is an isomerization, in which G6P is converted to fructose 6-phosphate (F6P). The enzyme catalyzing this reaction is glucose-6-phosphate isomerase, GPI (also known as phosphohexose isomerase, PHI; or phosphoglucose isomerase, PGI). The reaction is freely reversible at normal cellular concentrations of the two hexose phosphates and thus catalyzes this interconversion during glycolytic carbon flow and during gluconeogenesis. The GPI gene is located on chromosome 19q13.11 spanning 40 kb and composed of 20 exons that generate seven alternatively spliced mRNAs that collectively encode five protein isofoms.
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