|Topic:||Aldolase A (Fructose-1,6-bisphosphate Aldolase): .|
|Details:|| Aldolase A catalyzes the hydrolysis of F1,6BP into two 3-carbon products: dihydroxyacetone phosphate (DHAP) and glyceraldehyde 3-phosphate (G3P). The aldolase A reaction proceeds readily in the reverse direction, being utilized for both glycolysis and gluconeogenesis. The aldolase A gene (gene symbol: ALDOA) is located on chromosome 16p11.2 and is composed of 17 exons that generate nine alternatively spliced mRNAs that encode two protein isoforms of 364 amino acids (isoform 1) and 418 amino acids (isoform 2).
There are three aldolase enzymes in humans, aldolase A, aldolase B, and aldolase C. The aldolase B enzyme is primarily involved in hepatic metabolism of fructose but is also expressed in the kidney and small intestine. The aldolase C enzyme is expressed primarily in the brain. The aldolase B enzyme is encoded by the ALDOB gene which is located on chromosome 9q31.1 and is composed of 9 exons that produce a protein of 364 amino acids. The aldolase C enzyme is encoded by the ALDOC gene which is located on chromosome 17q11.2 and is composed of 10 exons that produce a protein of 364 amino acids.
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